蛋白激酶样内质网激酶单克隆抗体

产品货号：

BN42065M
中文名称：

蛋白激酶样内质网激酶单克隆抗体
英文名称：

Mouse anti-EIF2AK3/PERK Monoclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN42065M-50ul

50ul

¥2020.00

交叉反应：Human,Mouse(predicted:Rat) 推荐应用：WB,ELISA
BN42065M-100ul

100ul

¥3240.00

交叉反应：Human,Mouse(predicted:Rat) 推荐应用：WB,ELISA

产品描述

英文名称	EIF2AK3/PERK
中文名称	蛋白激酶样内质网激酶单克隆抗体
别名	DKFZp781H1925; E2AK3_HUMAN; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2 alpha kinase 3; Eukaryotic translation initiation factor 2-alpha kinase 3; Heme regulated EIF2 alpha kinase; HRI; HsPEK; Pancreatic eIF2 alpha kinase; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; PRKR-like endoplasmic reticulum kinase; WRS.
研究领域	免疫学染色质和核信号信号转导新陈代谢表观遗传学
抗体来源	Mouse
克隆类型	Monoclonal
克隆号	3C3
交叉反应	Human, Mouse, (predicted: Rat, )
产品应用	WB=1:200-1000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	122kDa
细胞定位	细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	Recombinant human EIF2AK3:
亚型	IgG1
纯化方法	affinity purified by Protein G
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010] Function: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Subunit: Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3. Subcellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Tissue Specificity: Ubiquitous. A high level expression is seen in secretory tissues. Post-translational modifications: Oligomerization of the N-terminal ER luminal domain by ER stress promotes PERK trans-autophosphorylation of the C-terminal cytoplasmic kinase domain at multiple residues including Thr-982 on the kinase activation loop. Autophosphorylated. Phosphorylated at Tyr-619 following endoplasmic reticulum stress, leading to activate its tyrosine-protein kinase activity. Dephosphorylated by PTPN1/TP1B, leading to inactivate its enzyme activity. N-glycosylated. ADP-ribosylated by PARP16 upon ER stress, which increases kinase activity. DISEASE: Wolcott-Rallison syndrome (WRS) [MIM:226980]: A rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. Contains 1 protein kinase domain. SWISS: Q9NZJ5 Gene ID: 9451 Database links: Entrez Gene: 9451 Human Entrez Gene: 13666 Mouse Entrez Gene: 29702 Rat Omim: 604032 Human SwissProt: Q9NZJ5 Human SwissProt: Q9Z2B5 Mouse SwissProt: Q9Z1Z1 Rat Unigene: 591589 Human Unigene: 247167 Mouse Unigene: 24897 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.