1号染色体开放阅读框19抗体

产品货号：

BN41407R
中文名称：

1号染色体开放阅读框19抗体
英文名称：

Rabbit anti-C1orf19 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41407R-100ul

100ul

¥2120.00

交叉反应（总）:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep,;推荐应用:IHC-P,
BN41407R-200ul

200ul

¥3140.00

交叉反应（总）:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep,;推荐应用:IHC-P,

产品描述

英文名称	C1orf19
中文名称	1号染色体开放阅读框19抗体
别名	Chromosome 1 open reading frame 19; Chromosome 1 open reading frame 19, isoform CRA_c; HsSen15; sen15; SEN15 homolog; SEN15_HUMAN; tRNA intron endonuclease Sen15; tRNA splicing endonuclease 15 homolog (S. cerevisiae); tRNA splicing endonuclease subunit Sen15; tRNA-intron endonuclease SEN15; tRNA-splicing endonuclease subunit SEN15; Tsen15.
研究领域	细胞生物免疫学细胞分化表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Sheep, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	19kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human C1orf19/SEN15:51-150/171
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	SEN15, also known as TSEN15 (tRNA-splicing endonuclease subunit Sen15) or C1orf19, is a nuclear protein that plays a role in tRNA splicing. Widely expressed with highest expression in testis and uterus, SEN15 is a non-catalytic subunit of the multi-protein tRNA-splicing endonuclease complex. The endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5’ and 3’ splice sites, thereby releasing introns and free tRNA molecules with 2',3' cyclic phosphates and 5'-OH termini. In addition to its role in pre-tRNA splicing, the endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. As a subunit of the complex, SEN15 participates in protein expression and, ultimately, cell growth and division. Function: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3' end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3' end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Subunit: Homodimer. tRNA splicing endonuclease is a heterotetramer composed of SEN2, SEN15, SEN34/LENG5 and SEN54. tRNA splicing endonuclease complex also contains proteins of the Pre-mRNA 3' end processing machinery such as CLP1, CPSF1, CPSF4 and CSTF2. Subcellular Location: Nucleus (Probable). Nucleus, nucleolus (Probable). Note=May be transiently localized in the nucleolus (Probable). Tissue Specificity: Widely expressed. Highly expressed in testis and uterus. Similarity: Belongs to the SEN15 family. SWISS: Q9H425 Gene ID: 84886 Database links: Entrez Gene: 84886 Human SwissProt: Q9H425 Human Unigene: 520494 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.