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产品规格
售价
备注
BN41361R-100ul
100ul
¥2120.00
交叉反应（总）:Human,Mouse,Rat,Dog,Horse,Sheep,;推荐应用:IHC-P,
BN41361R-200ul
200ul
¥3140.00
交叉反应（总）:Human,Mouse,Rat,Dog,Horse,Sheep,;推荐应用:IHC-P,
产品描述
| 英文名称 | AKIRIN1 |
| 中文名称 | AKIRIN1蛋白抗体 |
| 别 名 | AKIRIN 1; C1orf108; FLJ12666; OTTHUMP00000008669; RP11-781D11.2; STRF2; AKIR1_HUMAN. |
| 研究领域 | 细胞生物 免疫学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Rat, (predicted: Human, Mouse, Dog, Horse, Sheep, ) |
| 产品应用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AKIRIN1:101-192/192 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways. Subcellular Location: Nuclear Tissue Specificity: Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes. Similarity: Belongs to the akirin family. SWISS: Q9H9L7 Gene ID: 79647 Database links: Entrez Gene: 79647 Human Entrez Gene: 68050 Mouse Omim: 615164 Human SwissProt: Q9H9L7 Human SwissProt: Q99LF1 Mouse Unigene: 293563 Human Unigene: 27903 Mouse Unigene: 390996 Mouse Unigene: 486258 Mouse Unigene: 3674 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
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