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CD24抗体
  • 产å“è´§å·ï¼š
    BN40799R
  • 中文å称：
    CD24抗体
  • 英文å称：
    Rabbit anti-CD24 Polyclonal antibody
  • å“牌：
    Biorigin

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  • BN40799R-100ul

    100ul

    ¥2360.00

    交å‰å应：Human,Mouse,Rat 推è应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN40799R-200ul

    200ul

    ¥3490.00

    交å‰å应：Human,Mouse,Rat 推è应用：WB,IHC-P,IHC-F,IF,ELISA

产å“æè¿°

英文å称CD24
中文å称CD24抗体
别    åCD 24; CD24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD24 antigen; CD24 molecule; CD24_HUMAN; CD24A; GPI linked surface mucin; Heat stable antigen; HSA; Nectadrin; Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; Cd24; Cd24a; Ly-52.  
研究领域肿瘤  ç»†èƒžç”Ÿç‰©  å…ç–«å­¦  ç¥žç»ç”Ÿç‰©å­¦  ä¿¡å·è½¬å¯¼  å¹²ç»†èƒž  ç»†èƒžç²˜é™„分孠 ç³–蛋白  ç»†èƒžç±»åž‹æ ‡å¿—物  t-淋巴细胞  b-淋巴细胞  éª¨é«“细胞  
抗体æ¥æºRabbit
克隆类型Polyclonal
交å‰å应Human, Mouse, Rat, 
产å“应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 ï¼ˆçŸ³èœ¡åˆ‡ç‰‡éœ€åšæŠ—原修å¤ï¼‰
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 å­ é‡3/8kDa
细胞定ä½ç»†èƒžè†œ 
性    çŠ¶Liquid
浓    åº¦1mg/ml
å… ç–« åŽŸKLH conjugated synthetic peptide derived from human CD24 :35-80/80 
亚    åž‹IgG
纯化方法affinity purified by Protein A
储 å­˜ æ¶²0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
ä¿å­˜æ¡ä»¶Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产å“介ç»CD24 (also known as heat stable antigen) is a phosphatidylinositol linked cell surface glycoprotein with a polypeptide core of 30 amino acids and high carbohydrate content. The apparent molecular mass of the two forms of CD24 purified from a mouse lymphoma cell line appear to be in the range of 40-60 and 23-30 kDa. CD24 is expressed at all stages of B cell development and on most thymocytes. The absence of expression from mature T cells is closely associated with their maturation from CD4+ CD8+ CD24+ thymocytes to either CD4+ CD8- CD24- or CD4- CD8+ CD24- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes. Its ligand is P selectin (CD62P). CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes. CD24 is also a positive marker of pancreatic cancer.

Function:
Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.

DISEASE:
Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface.

Similarity:
Belongs to the CD24 family.

SWISS:
P25063

Gene ID:
100133941

Database links:

Entrez Gene: 100133941 Human

Entrez Gene: 12484 Mouse

Entrez Gene: 25145 Rat

Omim: 600074 Human

SwissProt: P25063 Human

SwissProt: P24807 Mouse

SwissProt: Q07490 Rat

Unigene: 644105 Human

Unigene: 721443 Human

Unigene: 29742 Mouse

Unigene: 6007 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神ç»å¹²ç»†èƒžæ ‡å¿—物 肿瘤标志物 CD24是一ç§ä½Žåˆ†å­è´¨é‡é«˜åº¦ç³–基化的é»é™„分å­, 主è¦è¡¨è¾¾åœ¨é€ è¡€ç³»ç»Ÿ. 最近研究表明, 在造血系统肿瘤和一些器官的实体瘤表é¢å¯è§CD24高表达。近几年很多学者认为：CD24在å‰åˆ—腺癌ã€éžå°ç»†èƒžè‚ºç™Œã€é¼»å’½ç™Œã€åŽŸå‘性è‚细胞癌ã€èƒ†ç®¡ç»†èƒžç™Œã€éº¦å…‹å°”细胞癌ã€ç¥žç»æºæ€§è‚¿ç˜¤ã€èƒ°è…ºç™Œã€èƒƒç™Œã€ç»“肠癌ã€è‚¾ç»†èƒžç™Œã€B细胞